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Posts Tagged ‘Medicine’

This is a follow-up from our last post where Paul Schaffer, Head of the Nuclear Medicine Division at TRIUMF, was talking about his experience of being in the media spotlight. In this post, Paul talks more in-depth about the science of medical isotopes.

It all started 19 months ago. A grant that would forever change my perspective of science geared specifically toward innovating a solution for a critical unmet need—in this situation, it was the global isotope crisis. In 2010, not too long out of the private sector, I was already working on an effort funded by NSERC and CIHR through the BC Cancer Agency to establish the feasibility of producing Tc-99m—the world’s most common medical isotope—on a common medical cyclotron. The idea: produce this isotope where it’s needed, on demand, every day, if and when needed. Sounds good, right? The problem is that the world had come to accept what would have seemed impossible just 50 years ago.

The current Tc-99m production cycle, which uses nuclear reactors. Image courtesy of Nordion.

We are currently using a centralized production model for this isotope with just a six hour half-life. This model involves just a handful of dedicated, government-funded research reactors, producing molybdenum-99 from highly enriched uranium (which is another issue for another time). Moly, as we’ve come to affectionately call it, decays via beta emission to technetium, and when packaged into alumina columns, is sterilized, and encased in a hundred pounds of lead. It is then shipped by the thousands to hospitals around the world. The result: the world has come to accept Tc-99m, which is used in 85% of the 20 to 40 million patient scans every year as an isotope available from a small, 100 pound cylinder that was replaced every week or so, without question, without worry. Moly and her daughter were always there…but in 2007 and again in 2009, suddenly they weren’t. The world had come to realize that something must be done.

In the middle of our NSERC/CIHR effort, we were presented with an opportunity to write a proof-of-concept grant based on the proof-of-feasibility we were actively pursuing. Luckily, the team had come far enough to believe we were on the right track. We believed that large scale curie-level production of Tc-99m using existing cyclotron technology was indeed possible. The ensuing effort was—in contrast to the current way of doing things—ridiculous.

With extensive, continuous input from several top scientists from around the country, I stitched together a document 200 pages long. It was a grant that was supposed to redefine how the most important isotope in nuclear medicine was produced. 200 pages, well 199 to be exact, describing a process—THE process—we were hopefully going to be working on for the next 18 months. We waited…success! And we began.

The effort started the same way as the document – with nothing more than a blank piece of paper. Blank in the sense that we knew what we had to do, we just had not defined exactly how we were going to achieve our goal. But what happened next was a truly remarkable thing; with that blank sheet, I witnessed first-hand a team of people imagine a solution, roll up their sleeves and turn those notions into reality.

If you would like to read the PET report, click here

 

 

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Paul Schaffer is the head of the Nuclear Medicine Division at TRIUMF. For the past 18 months, he and his team have been devising a method for Canada and the world to have an alternative way to produce medical isotopes. Currently, these isotopes are created on aging nuclear reactors, which are beginning to show signs of wear by needing emergency repairs. These repairs stop the flow of isotopes, affecting hundreds of thousands of people around the world. This is an inside perspective of what it means to work on the front line, and be in the media spotlight.

I’m going to start this post with the day I had the privilege of standing in front of a group of reporters along with a few of my esteemed colleagues to announce that we had, in fact, delivered on a promise we had made just over a year ago; the promise of making medical isotopes with existing hospital cyclotrons. We had set out to prove that it was possible to produce Tc-99m on a small medical cyclotron and at quantities sufficient to supply a large urban centre. The solution to Tc-99m shortages is to decentralize production. It was an example of Canadian innovation at its best – by taking a group of existing machines in existing facilities already tasked at making various other medical isotopes and extending the functionality of those facilities to produce another isotope.

Paul presenting his team's findings

The response from the press was remarkable to witness. The interest was swift, broad, and far reaching. The 24-hour news cycle had begun and with it came a deluge of requests for radio, TV, and print interviews. In the ensuing days I read a number of wonderful reports from capable reporters, often writing about a topic well outside of their background or familiarity. For that, I admire the work that they collectively pulled together in the short amount of time involved.

Something else happened, though; something I didn’t anticipate – the ensuing media blitz ended up becoming a very personal social experiment, an intense self-examination. On the way to my first-ever national television interview, I can distinctly remember reality sinking in—for most of my life, I’ve dealt with significant hearing loss. In my ever-quiet world, acutely and perpetually punctuated by tinnitus, verbal communication can be a consuming task.

It is a fact that I comprehend only 33% of the words spoken to me and that my brain fills the gaps using whatever facts it can absorb from my surroundings—expressions, moving lips, and other non-verbal cues. In that car on the way to the interview, I couldn’t help but to continuously wonder about how I would handle verbal questions on camera? What do you say on live TV when you can’t for the life of you figure out what your conversational counterpart is saying? My wingman kept reassuring me, giving background from experience and many, many reassuring comments; but deep down I had to wonder, was this the moment when the whole situation would finally come undone? My charade of being able to hear the world around me would finally end. Worse still, had the moment come to sell the team’s amazing accomplishments on national TV, with a significant number of people literally watching; and all I kept wondering was: will it fall apart simply over an unheard or misinterpreted question? Good thing most communication is non-verbal.

The interview ended up being remote, with the reporters in Ontario and a conspicuous 5 second ‘safety’ delay between what I thought I heard and what showed up on the TV monitor facing me. Five seconds was long enough for them to cut out a fleeting wardrobe malfunction, should I become a bit too passionate during my scientific descriptions, but not nearly long enough to spare a poor soul a repeat question. So, seated in a large, empty, and thankfully quiet studio it began with a single chair, bright lights, and an audio test – ‘please count to 5’ came in over the ear piece…this out of context and no non-verbal queue jolted my fear into reality. I couldn’t understand the question. Out of the corner of my eye, I could see my wingman turn a shade lighter. Worry was setting in. The in-studio producer was almost dumbstruck – this ‘expert’ couldn’t count to five.  45 seconds to ‘go’ and he repeated the question. I got it, counted to five….30 seconds….15, an ambulance was coming, getting louder, I couldn’t hear the commercial any longer…..10, the ambulance was on the street directly below. I had to look away from the TV screen, as the delay was overwhelmingly distracting. 5 seconds. The sirens were starting to recede and before you knew it, I was live.

Paul on CTV News

At first I didn’t want to watch the interview, but family, friends and colleagues from across Canada starting chiming in and eventually convinced me to watch. I felt satisfied with the results, relieved that I had heard every question, answered everything without wandering or forgetting what the question was, covering the topics I wanted to cover. However, I was definitely watching an objective projection of somebody I wasn’t familiar with. I won’t get into the details of what I saw – it’d be different for everyone, but the experience has been life altering, as has this project. That said, I’m proud of the team that has worked so well and so hard together for the past 18 months. It’s been a remarkable project on all fronts. Whether our results continue to keep their momentum and become a permanent solution to the isotope issues that plagued us for two years remains to be seen. I do know success when I see it, and this team of Canadian scientists, engineers, and medical professionals should all be immensely proud of what they have done. They are Canadian innovation at its best.

The team of TRIUMF scientists Paul collaborated with on the groundbreaking project

 

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Update I: Included Medicine Award (Oct 03)

Update II: Included Physics Award (Oct 04)

… it’s Nobel Week! October means three things: Halloween (duh), Fall, and Nobel Week, the week during which the famed prizes are awarded to those who have “conferred the greatest benefit on mankind” [1]. Okay, before I get comments about the subjectivity of those who award the prizes, I gladly admit that the history of the prize is not without controversy relating to those who have & have not won, in both the science and non-science categories.

I am just going to ignore all of that and talk about why everyone should be excited about this week. Though before I talk about this week’s Nobels, I feel I should probably give the SparkNotes version of the prizes’ history.

Figure 1: The 2008 Chemistry Prize was awarded for the discovery and development of green fluorescent protein (GFP), which when inserted into a soon-to-be parent is passed onto an offspring who can then glow green. Glowing cat!
(Image: The Nobel Foundation)

[1] http://www.nobelprize.org/alfred_nobel/will/will-full.html

A Brief History of Alfred Nobel

Figure 2: Alfred Nobel. (Image: The Nobel Foundation)

The year is 1866, the Second Industrial Revolution is raging, innovation is surging, and the US Civil War over.

Insert Alfred Nobel: A son of a successful engineer who developed controlled explosives for the demolition and mining industries. The younger Nobel, unsurprisingly, decided be a chemist after playing with nitroglycerin in a French laboratory. As a public service announcement, I should probably mention that nitroglycerin is very dangerous and is a principle ingredient in dynamite. In fact, Nobel was so convinced that nitroglycerine had useful application in construction that he decided to invent dynamite. Needless to say, dynamite made Nobel a very, very, very rich man. At the end of his life, he decided to endow, with the bulk of his fortune, a set of prizes to recognize those who have contributed greatest in the Fields of Medicine, Physics, Chemistry, Literature, and Peace. Economics, though not stipulated in the original will, was added later and is funded separately.

Figure 2: The chemical structure of nitroglycerin. This stuff is wicked; the physical chemistry behind its structure worth a gander. Consider this an advertisement to go earn a chemistry degree. (Image: Wikipedia)

What Makes a Prize

The Nobels has come a long way since they were first instituted. Most notably, they no longer are awarded for the greatest discovery or invention from the past year; the prizes now award those results with the most lasting influence and impact. Take last year for example. The 2011 award for Physiology or Medicine went solely to Sir Robert Edwards for having developed in vitro fertilization. You would think something that is, in every sense of the word, responsible for the existence of millions of people would have been awarded long, long ago. I mean, that is what went through my mind last October. Therein lies the novelty of the Nobel Prizes: These days, the awards are given to what seem like common knowledge, because in some sense they are. What one has to realize though is that prior a laureate’s discovery or invention, these ideas and concepts just did not exist. Imagine a world in which no one knew of insulin (Nobel 1923). Weird, no?

This brings me to why Nobel Week is so much fun. Sometimes you know quite a bit about the award-winning discovery and so you get to spend the day reading news articles and science blogs learning all about the topic’s history. Werner Forssmann’s invention of the cardiac catheter (Nobel 1953) has a hysterical history that is well worth a read. At other times, you have no idea what the award citation even means, but you just know it is worth spending a few minutes or even a few hours learning. I mean, why else would a Nobel be awarded? Take, as another example, 2008′s Physics prize. The award citation reads:

“… for the discovery of the mechanism of spontaneous broken symmetry in subatomic physics,” [2]

and

“for the discovery of the origin of the broken symmetry
which predicts the existence of at least three families of quarks in nature
.” [2]

Yup, it is a mouthful and probably seems a bit obtuse. That is, until you start looking up Wikipedia or news articles (or Quantum Diaries!), and realize how amazingly awesome these discoveries are. I mean, sure discovering spontaneous symmetry breaking (SSB) sounds nice and fancy but did you know that is why the bosons in the Standard Model of Physics have the masses they do?!? SSB, when applied specifically to the Electroweak bosons (photon, W, & Z) is the Higgs Mechanism, and when applied to fermions, is what generates the higgs boson. SSB is an established scientific fact and is also the driving force behind superconductivity (Nobel 1972) Whether or not the higgs boson exists, however, is completely different story.

Figure 3: The quark sector of the Standard Model of Particle Physics and their discovery dates. (Image: Nobel Foundation)

So back in 1977 a Fermilab team, led by Leon Lederman, discovered the bottom quark (Nobel 1988), and in 1995, the CDF & DZero Tevatron experiments discovered the top quark. Ever wonder how we knew to look for them in the first place? It was because of something called the CKM matrix. It was introduced as a way of organizing the the different ways particles in the Standard Model could interact and decay. However, as gorgeous as this new organization was, in order to work the CKM matrix required the existence of two new quarks. Well guess what, Fermilab found those two quarks and set the Standard Model in stone.

The 2009 Nobel Prizes are equally impressive. Half the prize was awarded for the development of fiber optics, which is the foundation of modern telecommunications, and something called Charged-Coupled Devices (CCD). What took me a few hours to learn is that if you take this sensor, attach a flashbulb, a battery, and maybe a memory card, you get a digital camera. In other words, half the 2009 prize was awarded for inventing the digital camera. The prize winners were simply trying to develop a better way of storing data and inadvertently created an entire industry. A fun fact: the first transistor (Nobel 1967) was made of paperclips. If you are curious about what makes transistors so important, take apart your computer and take a peek. (Please, make sure the computer is unplugged before opening it.)

[2] http://www.nobelprize.org/nobel_prizes/physics/laureates/2008/

Does Every Major Discovery/Invention Get a Prize?

No. First off, Nobel Prizes are no longer awarded posthumously. Secondly, from my discussions about this issue, there seems to be a consensus there may be a limit to what is & is not awarded when it comes to the sciences. Now the Swedish Academies always reserve the right to set a new precedent, however, it is unlikely that any organizations will be awarded a Nobel in science categories anytime soon. (This is the complete opposite for the Peace Prize, of course.) What does this all mean? Well, the top quark was a pretty heavy discovery and is well worth its weight in gold, at least in my opinion. However, to whom would you award the prize? No single person at the CDF experiment can justly say she or he discovered the quark; it was a team effort and all CDF personnel can proudly state she or he helped discover the quark.

“Which of the Gang of Six, if the higgs boson is discovered, should get the Nobel, if at all?” is an honest, open question and is well above my pay grade. A similar statement could be made about Supersymmetry.

Turning Nobel Week into Fun-bel Week

Now for the fun part. So during this week, pick your favorite subject, which of course is physics, and go figure out what the whole big hubbub is. Depending on your timezone, this may either be with your morning coffee or afternoon tea. In any case, it is an excuse to learn something new! :)

Alternatively, you can check back here Tuesday afternoon (Madison/Chicago time) because I am sure many of us will be commenting on the latest news.

This Week’s Schedule

Live Video Player here.

Physiology or Medicine – Awarded for the discovery of the innate and adaptive immune systems! Okay, really this is great. The human body has evolved to be inherently immune to certain pathogens. The human body, in its resourcefulness, can also adapt and become immune to pathogens. The end result is that when the two are combined and wait a few hundred thousand years,  you get us!

Physics – Awarded for discovering that expansion rate of the universe, is itself increasing. The universe expands, Edwin Hubble discovered that decades ago. Today’s award winners discovered that the universe expands at an accelerating rate! Bravo!

Chemistry – The prize will be announced on Wednesday 5 October, 11:45 a.m. CET [5:45 am  CDT/Chicago].

Peace – The prize will be announced on Friday 7 October, 11:00 a.m. CET [5:00 am  CDT/Chicago].

Economics – The prize will be announced on Monday 10 October, 1:00 p.m. CET [7:00 am  CDT/Chicago].

Literature – To Be Announced

 

 

 

 

Regardless of the outcome, I would love to read everyone’s thoughts and speculations before and after the awards!

Happy Colliding

- richard (@bravelittlemuon)

 

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