This is a follow-up from our last post where Paul Schaffer, Head of the Nuclear Medicine Division at TRIUMF, was talking about his experience of being in the media spotlight. In this post, Paul talks more in-depth about the science of medical isotopes.
It all started 19 months ago. A grant that would forever change my perspective of science geared specifically toward innovating a solution for a critical unmet need—in this situation, it was the global isotope crisis. In 2010, not too long out of the private sector, I was already working on an effort funded by NSERC and CIHR through the BC Cancer Agency to establish the feasibility of producing Tc-99m—the world’s most common medical isotope—on a common medical cyclotron. The idea: produce this isotope where it’s needed, on demand, every day, if and when needed. Sounds good, right? The problem is that the world had come to accept what would have seemed impossible just 50 years ago.
The current Tc-99m production cycle, which uses nuclear reactors. Image courtesy of Nordion.
We are currently using a centralized production model for this isotope with just a six hour half-life. This model involves just a handful of dedicated, government-funded research reactors, producing molybdenum-99 from highly enriched uranium (which is another issue for another time). Moly, as we’ve come to affectionately call it, decays via beta emission to technetium, and when packaged into alumina columns, is sterilized, and encased in a hundred pounds of lead. It is then shipped by the thousands to hospitals around the world. The result: the world has come to accept Tc-99m, which is used in 85% of the 20 to 40 million patient scans every year as an isotope available from a small, 100 pound cylinder that was replaced every week or so, without question, without worry. Moly and her daughter were always there…but in 2007 and again in 2009, suddenly they weren’t. The world had come to realize that something must be done.
In the middle of our NSERC/CIHR effort, we were presented with an opportunity to write a proof-of-concept grant based on the proof-of-feasibility we were actively pursuing. Luckily, the team had come far enough to believe we were on the right track. We believed that large scale curie-level production of Tc-99m using existing cyclotron technology was indeed possible. The ensuing effort was—in contrast to the current way of doing things—ridiculous.
With extensive, continuous input from several top scientists from around the country, I stitched together a document 200 pages long. It was a grant that was supposed to redefine how the most important isotope in nuclear medicine was produced. 200 pages, well 199 to be exact, describing a process—THE process—we were hopefully going to be working on for the next 18 months. We waited…success! And we began.
The effort started the same way as the document – with nothing more than a blank piece of paper. Blank in the sense that we knew what we had to do, we just had not defined exactly how we were going to achieve our goal. But what happened next was a truly remarkable thing; with that blank sheet, I witnessed first-hand a team of people imagine a solution, roll up their sleeves and turn those notions into reality.
If you would like to read the PET report, click here
